Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 5/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | NPY1R | P25929 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369351 | 0.99 | NPC1 (0.48) | HTTNPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL7369285 | 0.92 | EGFR (0.48) | KDM4ESMN1; SMN2ALDH1A1EGFR | |
| SCHEMBL7370244 | 0.83 | SPHK2 (0.47) | SIRT2 | |
| SCHEMBL7372540 | 0.82 | NPC1 (0.47) | HTTNPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL7339414 | 0.82 | TACR2 (0.46) | HTTNPC1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL7336886 | 0.81 | TACR2 (0.45) | NPC1RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL7373069 | 0.80 | TDP1 (0.45) | NPC1RAB9ASMN1; SMN2ALDH1A1SIRT2 | |
| SCHEMBL7369224 | 0.79 | QPCT (0.54) | HTTKDM4ESMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL7375298 | 0.78 | NPC1 (0.43) | NPC1RAB9ASIRT2 | |
| SCHEMBL9785827 | 0.74 | MET (0.53) | HTTNPC1RAB9AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998054123-A1 | SUBSTITUTED PEPTIDYLAMINE CALCIUM CHANNEL BLOCKERS | WARNER-LAMBERT COMPANY (US) | 1998-12-03 | — | — | WO | claimed |
| WO-1998054123-A1 | SUBSTITUTED PEPTIDYLAMINE CALCIUM CHANNEL BLOCKERS | WARNER-LAMBERT COMPANY (US) | 1998-12-03 | — | — | WO | disclosed |