Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 2/20 | 0.38 |
| ▸ | MMP9 | P14780 | 2/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7275829 | 1.00 | ADRA1D (0.41) | ADRA1DADRA1AADRA1BUSP2SMN1; SMN2 | |
| SCHEMBL8402001 | 0.84 | ADRA1D (0.41) | ADRA1DADRA1AADRA1BSMN1; SMN2ALDH1A1 | |
| SCHEMBL8402002 | 0.84 | ADRA1D (0.41) | ADRA1DADRA1AADRA1BSMN1; SMN2ALDH1A1 | |
| SCHEMBL8402249 | 0.84 | ADRA1D (0.41) | ADRA1DADRA1AADRA1BSMN1; SMN2ALDH1A1 | |
| SCHEMBL27567585 | 0.83 | USP2 (0.45) | USP2SMN1; SMN2EPHX1MAPK1PTPN2 | |
| SCHEMBL24940 | 0.82 | USP2 (0.41) | USP2SMN1; SMN2EPHX1MAPK1PTPN2 | |
| SCHEMBL1350453 | 0.82 | USP2 (0.41) | USP2SMN1; SMN2EPHX1MAPK1PTPN2 | |
| SCHEMBL881661 | 0.82 | USP2 (0.41) | USP2SMN1; SMN2EPHX1MAPK1PTPN2 | |
| SCHEMBL13907982 | 0.82 | ADRA1D (0.40) | ADRA1DADRA1AADRA1BSMN1; SMN2KMT2A | |
| SCHEMBL2392691 | 0.82 | USP2 (0.44) | USP2SMN1; SMN2EPHX1MAPK1PTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090068719-A1 | IMMUNOASSAYS, HAPTENS, IMMUNOGENS AND ANTIBODIES FOR ANTI-HIV THERAPEUTICS | VALDEZ JOHNNY | 2009-03-12 | — | — | US | disclosed |
| US-20010008892-A1 | Retroviral protease inhibiting compounds | CHEN XIAOQI (US) | 2001-07-19 | — | — | US | disclosed |
| US-6251906-B1 | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES | 2001-06-26 | — | — | US | disclosed |
| EP-0756593-B1 | PROCESS FOR PREPARING 2-PIPERAZINE CARBOXYLIC ACID DERIVATIVES | LONZA AG (CH) | 2000-09-20 | — | — | EP | disclosed |
| US-5886181-A | ASYMMETRIC HYDROGENATION OF THE CORRESPONDING 1,4,5,6-TETRAHYDROPYRAZINES | LONZA, LTD. (CH) | 1999-03-23 | — | — | US | disclosed |
| US-5856485-A | RESOLUTION OF AN ENANTIOMORPH MIXTURE | LONZA AG (CH) | 1999-01-05 | — | — | US | disclosed |
| US-5792869-A | REACTING PIPERAZINE DERIVATIVE WITH SULFONAMIDE DERIVATIVE OF OPTICALLY ACTIVE AMINO ACID, PRECIPITATING LESS SOLUBLE SALT, SEPARATING, DECOMPOSING TO DESIRED DIASTEREOMER | YAMAKAWA CHEMICAL INDUSTRY CO., LTD (JP) | 1998-08-11 | — | — | US | disclosed |
| EP-0710652-B1 | Process for preparing optically active piperazine derivatives and intermediates for preparation | YAMAKAWA CHEMICAL IND (JP) | 1998-03-04 | — | — | EP | disclosed |
| US-5650412-A | VIRICIDES, IMMUNOMODULATORS, ANTIBIOTICS OR VACCINES | MERCK & CO., INC. (US) | 1997-07-22 | — | — | US | disclosed |
| US-5612339-A | BACTERICIDES OR ANTISEPTICS | TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1997-03-18 | — | — | US | disclosed |
| EP-0756593-A1 | PROCESS FOR PREPARING 2-PIPERAZINE CARBOXYLIC ACID DERIVATIVES | LONZA AG (CH) | 1997-02-05 | — | — | EP | disclosed |
| WO-1996022097-A1 | NOVEL 2-HYDROXY-3-AMINOPROPYLSULFONAMIDES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1996-07-25 | — | — | WO | disclosed |
| US-5519060-A | ENZYME INHIBITORS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 1996-05-21 | — | — | US | disclosed |
| EP-0710652-A2 | Process for preparing optically active piperazine derivatives and intermediates for preparation | YAMAKAWA CHEMICAL INDUSTRY CO., LTD. (JP) | 1996-05-08 | — | — | EP | disclosed |
| WO-1995029169-A2 | PROCESS FOR PREPARING 2-PIPERAZINE CARBOXYLIC ACID DERIVATIVES | LONZA AG (CH) | 1995-11-02 | — | — | WO | disclosed |
| WO-1994018192-A1 | PIPERAZINE DERIVATIVES AS HIV PROTEASE INHIBITORS | MERCK & CO., INC. (US) | 1994-08-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090068719-A1 | IMMUNOASSAYS, HAPTENS, IMMUNOGENS AND ANTIBODIES FOR ANTI-HIV THERAPEUTICS | CD4, MPI, ME1 | ADRA1D 3855/4885ADRA1A 2882/4885ADRA1B 3222/4885 |
| US-20010008892-A1 | Retroviral protease inhibiting compounds | PREP, DNPEP, SERPINB1 | ADRA1D 4828/4885ADRA1A 4838/4885ADRA1B 4803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.