Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.40 |
| ▸ | TOP1 | P11387 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7366044 | 0.91 | TP53 (0.45) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7365100 | 0.91 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7369334 | 0.88 | ALDH1A1 (0.48) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7366870 | 0.85 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7363892 | 0.84 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7366158 | 0.84 | PDE4A (0.74) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7367898 | 0.82 | TBXAS1 (0.48) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7365112 | 0.81 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7368033 | 0.80 | PIK3CD (0.50) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7370566 | 0.79 | MEN1 (0.51) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |