Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 4/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.44 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370605 | 0.91 | KDM4E (0.48) | ALDH1A1KDM4EHPGDTHRBRXFP1 | |
| SCHEMBL7365416 | 0.91 | ALDH1A1 (0.50) | ALDH1A1KDM4EHPGDTHRBRXFP1 | |
| SCHEMBL7368038 | 0.88 | PDE4A (0.52) | THRBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7370566 | 0.87 | MEN1 (0.51) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7366074 | 0.84 | PDE4A (0.55) | ALDH1A1KDM4EHPGDTHRBRXFP1 | |
| SCHEMBL7365157 | 0.83 | PDE4A (0.66) | ALDH1A1KDM4EHPGDTHRBRXFP1 | |
| SCHEMBL7369488 | 0.83 | HPGD (0.50) | ALDH1A1HPGDPDE4APDE4BPDE4C | |
| SCHEMBL7362436 | 0.82 | SMN1; SMN2 (0.47) | ALDH1A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7365028 | 0.81 | KDM4E (0.50) | ALDH1A1KDM4EHPGDTHRBRXFP1 | |
| SCHEMBL7362292 | 0.80 | PDE4A (0.51) | ALDH1A1KDM4EHPGDTHRBRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |