Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26A1 | O43174 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL622656 | 0.85 | IDO1 (0.50) | CYP26A1MEN1KMT2ASMN1; SMN2 | |
| Ammonia Solution, Strong SCHEMBL8172708 | 0.83 | IDO1 (0.48) | CYP26A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14862904 | 0.83 | MAOB (0.55) | — | |
| SCHEMBL3367622 | 0.82 | LTA4H (0.48) | — | |
| SCHEMBL3365060 | 0.82 | LTA4H (0.51) | — | |
| SCHEMBL4358923 | 0.81 | GLA (0.45) | CYP26A1GLAMEN1KMT2A | |
| SCHEMBL3964389 | 0.81 | CYP19A1 (0.47) | CYP26A1CYP19A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8008639 | 0.80 | OPRM1 (0.42) | — | |
| SCHEMBL6628369 | 0.80 | LTA4H (0.54) | SMN1; SMN2 | |
| Cyanide SCHEMBL27674740 | 0.80 | CYP26A1 (0.46) | CYP26A1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821251-A | USEFUL FOR BLOCKING VOLTAGE GATED POTASSIUM CHANNELS | JOHN WYETH & BROTHER LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |
| US-5753676-A | TREATMENT OF PSYCHOLOGICAL DISORDERS, NERVOUS SYSTEM DISORDERS | JOHN WYETH & BROTHER LIMITED (GB) | 1998-05-19 | — | — | US | disclosed |
| US-5681839-A | BLOCK VOLTAGE GATED POTASSIUM CHANNEL | JOHN WYETH & BROTHER (GB) | 1997-10-28 | — | — | US | disclosed |
| WO-1995021825-A1 | 6-ARYL-(METHYL- OR METHYLIDONE)-QUINOLINE DERIVATIVES AS VOLTAGE-GATED POTASSIUM CHANNEL BLOCKERS | JOHN WYETH & BROTHER LTD. (GB) | 1995-08-17 | — | — | WO | disclosed |
| WO-1995021824-A1 | 6-ARYL-(METHYL- OR METHYLIDENE)-QUINOL-2-ONE DERIVATIVES AS VOLTAGE GATED POTASSIUM CHANNEL BLOCKERS | JOHN WYETH & BROTHER LTD (GB) | 1995-08-17 | — | — | WO | disclosed |
| WO-1995021823-A1 | 6-ARYL-(METHYL- OR METHYLIDENE)-QUINOLINE DERIVATIVES AS VOLTAGE-GATED POTASSIUM CHANNEL BLOCKERS | JOHN WYETH & BROTHER LTD. (GB) | 1995-08-17 | — | — | WO | disclosed |