Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 4/20 | 0.45 |
| ▸ | THRA | P10827 | 3/20 | 0.45 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | TYR | P14679 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7120194 | 0.82 | THRB (0.42) | THRBTHRARORCADRA2AADRA1A | |
| SCHEMBL6267786 | 0.78 | THRB (0.40) | THRBTHRARORCADRA2AADRA1A | |
| SCHEMBL6268323 | 0.77 | THRB (0.39) | THRBTHRARORCADRA2AADRA1A | |
| SCHEMBL6267801 | 0.75 | THRA (0.62) | THRBTHRAADRA2AADRA1ACYP2D6 | |
| SCHEMBL739698 | 0.71 | HDAC4 (0.48) | THRBRORCADRA2AADRA1ACYP2D6 | |
| SCHEMBL3942938 | 0.70 | PPARG (0.55) | BCHETYRACHEPPARGPPARD | |
| SCHEMBL7114452 | 0.70 | THRB (0.50) | THRBTHRARORCADRA2AADRA1A | |
| SCHEMBL7114179 | 0.69 | PTGS1 (0.50) | GAATSHRMAPTHPGDCYP3A4 | |
| SCHEMBL6866214 | 0.68 | THRB (0.40) | THRBTHRARORCMEN1KMT2A | |
| SCHEMBL13395132 | 0.68 | CYP2D6 (0.42) | THRBRORCADRA2AADRA1ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0991618-A4 | SELECTIVE THYROID HORMONE ANALOGS | UNIV CALIFORNIA (US) | 2000-09-27 | — | — | EP | disclosed |
| EP-0991618-A1 | SELECTIVE THYROID HORMONE ANALOGS | The Regents of the University of California (US) | 2000-04-12 | — | — | EP | disclosed |
| WO-1998057919-A1 | SELECTIVE THYROID HORMONE ANALOGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-12-23 | — | — | WO | disclosed |