Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7368101 | 0.82 | THRB (0.45) | THRBTHRACYP2D6ADRA2AADRA1A | |
| SCHEMBL6267801 | 0.81 | THRA (0.62) | THRBTHRACYP2D6ADRA2AADRA1A | |
| SCHEMBL6267786 | 0.81 | THRB (0.40) | THRBTHRACYP2D6ADRA2AADRA1A | |
| SCHEMBL6268323 | 0.80 | THRB (0.39) | THRBTHRACYP2D6ADRA2AADRA1A | |
| SCHEMBL739698 | 0.76 | HDAC4 (0.48) | THRBCYP2D6ADRA2AADRA1AGAA | |
| SCHEMBL13395132 | 0.73 | CYP2D6 (0.42) | THRBCYP2D6ADRA2AADRA1AGAA | |
| SCHEMBL10360993 | 0.73 | CYP2D6 (0.46) | THRBCYP2D6ADRA2AADRA1AGAA | |
| SCHEMBL487152 | 0.73 | CYP2D6 (0.67) | THRBCYP2D6ADRA2AADRA1AGAA | |
| SCHEMBL6705742 | 0.72 | CYP2D6 (0.45) | THRBCYP2D6ADRA2AADRA1AGAA | |
| SCHEMBL282378 | 0.72 | AR (0.45) | THRBCYP2D6ADRA2AADRA1AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0991618-B1 | SELECTIVE THYROID HORMONE ANALOGS | UNIV CALIFORNIA (US) | 2003-11-12 | — | — | EP | disclosed |
| EP-0991618-A4 | SELECTIVE THYROID HORMONE ANALOGS | UNIV CALIFORNIA (US) | 2000-09-27 | — | — | EP | disclosed |
| EP-0991618-A1 | SELECTIVE THYROID HORMONE ANALOGS | The Regents of the University of California (US) | 2000-04-12 | — | — | EP | disclosed |
| US-5883294-A | THYROID HORMONE AGONIST | THE REGEANTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-03-16 | — | — | US | disclosed |
| WO-1998057919-A1 | SELECTIVE THYROID HORMONE ANALOGS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-12-23 | — | — | WO | disclosed |