Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 6/20 | 0.49 |
| ▸ | MMP2 | P08253 | 5/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7368207 | 0.99 | MMP9 (0.48) | MMP9MMP2RAB9AITGB3ITGA2B | |
| Hydrochloric Acid SCHEMBL7448629 | 0.99 | MMP9 (0.48) | MMP9MMP2RAB9AITGB3ITGA2B | |
| SCHEMBL7368863 | 0.89 | MMP9 (0.49) | MMP9MMP2RAB9ACA1CA2 | |
| Hydrochloric Acid SCHEMBL7369271 | 0.86 | PLAU (0.35) | MMP9MMP2RAB9AITGB3ITGA2B | |
| Trifluoroacetic Acid SCHEMBL7372457 | 0.85 | MMP9 (0.45) | MMP9MMP2RAB9AITGB3ITGA2B | |
| Hydrochloric Acid SCHEMBL6433893 | 0.84 | PKLR (0.36) | MMP2RAB9AITGB3ITGA2BCYP2C9 | |
| Hydrochloric Acid SCHEMBL7376136 | 0.82 | PLAU (0.48) | MMP9MMP2ITGB3MMP13ADAMTS4 | |
| Trifluoroacetic Acid SCHEMBL7368831 | 0.81 | F2 (0.46) | MMP9MMP2ITGB3ITGA2BALDH1A1 | |
| Hydrochloric Acid SCHEMBL7588548 | 0.80 | PLG (0.50) | MMP9MMP2MMP13ADAMTS4MMP7 | |
| SCHEMBL6437440 | 0.78 | PLAU (0.40) | KDM4EMEN1ALDH1A1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |