Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 5/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP8 | P22894 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7372508 | 1.00 | LMNA (0.43) | LMNASMN1; SMN2MAPTHPGDRAB9A | |
| SCHEMBL8605725 | 0.89 | ELANE (0.41) | LMNAALDH1A1KMT2A | |
| SCHEMBL8605131 | 0.89 | ELANE (0.41) | LMNAALDH1A1KMT2A | |
| SCHEMBL7371447 | 0.83 | CA12 (0.36) | POLBMMP2MMP9MMP8CYP2C19 | |
| SCHEMBL7434188 | 0.81 | ELANE (0.43) | LMNAHPGDGAAPOLBALDH1A1 | |
| SCHEMBL7429786 | 0.81 | ELANE (0.43) | LMNAHPGDGAAPOLBALDH1A1 | |
| SCHEMBL7368613 | 0.80 | NPC1 (0.35) | LMNAMAPTRAB9AL3MBTL1MMP2 | |
| SCHEMBL3036136 | 0.79 | KMT2A (0.49) | LMNASMN1; SMN2MAPTHPGDRAB9A | |
| SCHEMBL7977845 | 0.79 | NPC1 (0.49) | HPGDL3MBTL1GAAPOLBHRH3 | |
| SCHEMBL9580715 | 0.74 | TSHR (0.41) | LMNASMN1; SMN2MAPTGAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994010143-A1 | NEW SUBSTITUTED AZETIDINONES AS ANTI-INFLAMMATORY AND ANTIDEGENERATIVE AGENTS | MERCK & CO., INC. (US) | 1994-05-11 | — | — | WO | disclosed |