Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7439317 | 1.00 | ELANE (0.43) | ELANEKDM4EPOLBALDH1A1HPGD | |
| SCHEMBL7438107 | 0.88 | ELANE (0.41) | ELANEALDH1A1HPGDPTGS1SRD5A2 | |
| SCHEMBL9193358 | 0.87 | CYP4F2 (0.42) | ELANEALDH1A1LMNAGAAHTT | |
| SCHEMBL7429922 | 0.81 | MEN1 (0.38) | KDM4EPOLBALDH1A1HPGDHSD17B10 | |
| SCHEMBL6430665 | 0.75 | CA12 (0.36) | ELANEKDM4EPOLBALDH1A1HSD17B10 | |
| SCHEMBL9557803 | 0.74 | BCL9 (0.40) | KDM4EPOLBALDH1A1HSD17B10CA2 | |
| SCHEMBL7422689 | 0.73 | SRD5A1 (0.37) | ELANESRD5A2RXRARXRB | |
| SCHEMBL7368608 | 0.73 | NPC1 (0.35) | LMNA | |
| SCHEMBL6430758 | 0.72 | NPC1 (0.49) | ELANEKDM4EPOLBALDH1A1HPGD | |
| SCHEMBL8605728 | 0.70 | KDM4E (0.42) | KDM4EALDH1A1HPGDHSD17B10PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0500171-B1 | Improved process for the preparation of chiral 4-aryloxyazetidinones | MERCK SHARP & DOHME (GB) | 1997-11-12 | — | — | EP | disclosed |
| US-5310899-A | Process for the preparation of chiral 4-aryloxyazetidinones | MERCK SHARPE & DOHME LTD. | 1994-05-10 | — | — | US | disclosed |
| US-5229381-A | Inhibitors of leukocyte enzyme elastase | MERCK & CO., INC. (US) | 1993-07-20 | — | — | US | disclosed |
| EP-0500171-A2 | Improved process for the preparation of chiral 4-aryloxyazetidinones | MERCK SHARP & DOHME LTD. (GB) | 1992-08-26 | — | — | EP | disclosed |
| EP-0481671-A1 | New substituted azetidinones as anti-inflammatory and antidegenerative agents | MERCK & CO. INC. (US) | 1992-04-22 | — | — | EP | disclosed |