Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 7/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30202144 | 1.00 | EPHX1 (0.43) | EPHX1ACHENOD1ALDH1A1NPC1 | |
| Hydrochloric Acid SCHEMBL7656187 | 0.98 | EPHX1 (0.42) | EPHX1ACHENOD1ALDH1A1NPC1 | |
| SCHEMBL8088672 | 0.90 | ALDH1A1 (0.37) | ACHENOD1ALDH1A1SMN1; SMN2ITGB3 | |
| SCHEMBL17175410 | 0.87 | NOD1 (0.45) | EPHX1ACHENOD1ITGB3ITGA2B | |
| SCHEMBL7372859 | 0.87 | EPHX1 (0.43) | EPHX1ACHEALDH1A1NPC1RAB9A | |
| SCHEMBL7453134 | 0.87 | EPHX1 (0.43) | EPHX1ACHEALDH1A1NPC1RAB9A | |
| SCHEMBL480292 | 0.86 | EPHX1 (0.46) | EPHX1ACHEALDH1A1NPC1RAB9A | |
| SCHEMBL284168 | 0.86 | EPHX1 (0.46) | EPHX1ACHEALDH1A1NPC1RAB9A | |
| SCHEMBL9716662 | 0.86 | NOD1 (0.47) | NOD1ITGB3ITGA2B | |
| SCHEMBL6688677 | 0.86 | NOD1 (0.47) | NOD1ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224186-A2 | PYRIDYL-CONTAINING SPIROCYCLIC COMPOUNDS AS INHIBITORS OF FIBRINOGEN-DEPENDENT PLATELET AGGREGATION | COR THERAPEUTICS, INC. (US) | 2002-07-24 | — | — | EP | disclosed |
| WO-2001030780-A2 | PYRIDYL-CONTAINING SPIROCYCLIC COMPOUNDS AS INHIBITORS OF FIBRINOGEN-DEPENDENT PLATELET AGGREGATION | COR THERAPEUTICS, INC. (US) | 2001-05-03 | — | — | WO | disclosed |
| WO-2000043793-A1 | A FACS METHOD FOR DETECTION OF GPIIb/IIIa INHIBITOR DEPENDENT ACTIVATORS IN PLASMA SAMPLES | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-07-27 | — | — | WO | disclosed |
| EP-0784628-A1 | INHIBITORS OF INTERLEUKIN-1$g(b) CONVERTING ENZYME | Vertex Pharmaceuticals Incorporated (US) | 1997-07-23 | — | — | EP | disclosed |
| WO-1995035308-A1 | INHIBITORS OF INTERLEUKIN-1β CONVERTING ENZYME | VERTEX PHARMACEUTICALS INCORPORATED (US) | 1995-12-28 | — | — | WO | disclosed |