Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.38 |
| ▸ | QPCT | Q16769 | 3/20 | 0.35 |
| ▸ | QPCTL | Q9NXS2 | 3/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7368793 | 1.00 | CYP3A4 (0.41) | CYP3A4NAMPTXDHACVR1QPCT | |
| SCHEMBL5147033 | 0.81 | NR4A2 (0.44) | CYP3A4MAPTNPSR1IDO1CYP1A2 | |
| SCHEMBL5147034 | 0.81 | NR4A2 (0.44) | CYP3A4MAPTNPSR1IDO1CYP1A2 | |
| SCHEMBL7369110 | 0.81 | ALDH1A1 (0.48) | CYP3A4NAMPTXDHACVR1QPCT | |
| SCHEMBL2537432 | 0.80 | FBP1 (0.45) | MAPTNPSR1ALDH1A1LMNARXRA | |
| SCHEMBL2534469 | 0.80 | FBP1 (0.45) | MAPTNPSR1ALDH1A1LMNARXRA | |
| SCHEMBL28013104 | 0.75 | FBP1 (0.49) | CYP3A4NAMPTXDHTLR4TLR2 | |
| SCHEMBL8476911 | 0.75 | MMP2 (0.50) | MAPTNPSR1IDO1CYP1A2CYP2D6 | |
| SCHEMBL10761570 | 0.74 | KMT2A (0.48) | MAPTIDO1ALDH1A1 | |
| SCHEMBL10761564 | 0.74 | KMT2A (0.48) | MAPTIDO1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666858-B1 | 5-ARYLINDOLE DERIVATIVES AND THEIR USE AS SEROTONIN (5-HT 1) AGONISTS | PFIZER (US) | 2001-06-13 | — | — | EP | disclosed |
| EP-1094064-A1 | 5-arylindolederivatives and their use as serotonin(5-ht1)agonists | PFIZER INC. (US) | 2001-04-25 | — | — | EP | disclosed |
| EP-0666858-A1 | 5-ARYLINDOLE DERIVATIVES AND THEIR USE AS SEROTONIN (5-HT 1?) AGONISTS | PFIZER INC. (US) | 1995-08-16 | — | — | EP | disclosed |
| WO-1994010171-A1 | 5-ARYLINDOLE DERIVATIVES AND THEIR USE AS SEROTONIN (5-HT1) AGONISTS | PFIZER INC. (US) | 1994-05-11 | — | — | WO | disclosed |