Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 4/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12909247 | 0.76 | ACHE (0.46) | OPRK1ACHEKMT2AHTTSMN1; SMN2 | |
| SCHEMBL7373150 | 0.73 | ACHE (0.41) | OPRK1ACHEKMT2AHTTSMN1; SMN2 | |
| SCHEMBL7401408 | 0.72 | KMT2A (0.44) | KMT2AHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL4031243 | 0.71 | NPC1 (0.48) | OPRK1ACHEKMT2AHTTSMN1; SMN2 | |
| SCHEMBL21974177 | 0.69 | KMT2A (0.35) | ACHEKMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL7523472 | 0.69 | SIGMAR1 (0.44) | KMT2AHTTNPC1RAB9AMEN1 | |
| SCHEMBL30327110 | 0.69 | TSHR (0.57) | ACHEKMT2AHTTSMN1; SMN2NPC1 | |
| SCHEMBL12874500 | 0.68 | S1PR1 (0.46) | ACHEKMT2AHTTSMN1; SMN2NPC1 | |
| SCHEMBL3858388 | 0.67 | ACHE (0.69) | ACHEKMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL18228323 | 0.66 | MEN1 (0.37) | KMT2ASMN1; SMN2TSHRMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995027692-A1 | SUBTITUTED BIPHENYL TNF INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-10-19 | — | — | WO | disclosed |