Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.67 |
| ▸ | F10 | P00742 | 1/20 | 0.67 |
| ▸ | F7 | P08709 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 6/20 | 0.60 |
| ▸ | RAB9A | P51151 | 6/20 | 0.60 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.60 |
| ▸ | CBFB | Q13951 | 9/20 | 0.57 |
| ▸ | METAP2 | P50579 | 8/20 | 0.57 |
| ▸ | METAP1 | P53582 | 6/20 | 0.57 |
| ▸ | PKM | P14618 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30832867 | 0.81 | CHEK2 (0.82) | F2F10F7NPC1RAB9A | |
| SCHEMBL7371342 | 0.81 | F2 (1.00) | F2F10F7NPC1RAB9A | |
| SCHEMBL19982677 | 0.80 | F2 (0.65) | F2F10F7NPC1RAB9A | |
| SCHEMBL32660766 | 0.80 | F2 (0.65) | F2F10F7NPC1RAB9A | |
| SCHEMBL7368935 | 0.80 | F2 (0.71) | F2F10F7NPC1RAB9A | |
| SCHEMBL7402927 | 0.79 | F2 (0.62) | F2F10F7NPC1RAB9A | |
| SCHEMBL19970726 | 0.77 | F2 (0.70) | F2F10F7NPC1RAB9A | |
| SCHEMBL11035024 | 0.76 | METAP1 (0.70) | F2F10F7NPC1RAB9A | |
| SCHEMBL10351275 | 0.75 | NPC1 (1.00) | NPC1RAB9ARUNX1CBFBMETAP2 | |
| SCHEMBL4371835 | 0.73 | METAP2 (1.00) | F2F10F7NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6150379-A | BLOOD COAGULATION FACTOR XA INHIBITORS; TREATING DISEASES ASSOCIATED WITH SERINE PROTEASE ACTIVITY; THROMBOLYTIC AND ISCHEMIC AGENTS; E.G., 2-(6-(5-AMIDINO-1H-BENZIMIDAZOL-2-YL)-PYRID-3-YLCARBONYLAMINO)-3 -HYDROXYBUTYRIC ACID | AXYS PHARMACEUTICALS, INC. (US) | 2000-11-21 | — | — | US | disclosed |
| WO-1999026941-A1 | SUBSTITUTED AMIDINOARYL DERIVATIVES AND THEIR USE AS ANTICOAGULANTS | AXYS PHARMACEUTICALS, INC. (US) | 1999-06-03 | — | — | WO | disclosed |