Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | AGER | Q15109 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | DHODH | Q02127 | 4/20 | 0.51 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.46 |
| ▸ | CDC25B | P30305 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7347947 | 0.91 | ALDH1A1 (0.69) | KDM4EALDH1A1CYP3A4MAPTALOX15 | |
| Terephthalic Acid SCHEMBL28292423 | 0.89 | KDM4E (0.85) | KDM4EALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL7365695 | 0.88 | KDM4E (0.61) | KDM4EALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL7362610 | 0.88 | ALDH1A1 (0.61) | KDM4EALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL7842762 | 0.88 | KDM4E (0.61) | KDM4EALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL9172028 | 0.88 | ALDH1A1 (0.61) | KDM4EALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL10336997 | 0.87 | ALDH1A1 (0.80) | KDM4EALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL7367595 | 0.86 | KDM4E (0.67) | KDM4EALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL7362858 | 0.84 | KDM4E (0.56) | KDM4EALDH1A1CYP3A4MAPTALOX15 | |
| SCHEMBL7366419 | 0.84 | ALDH1A1 (0.56) | KDM4EALDH1A1CYP3A4MAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5716954-A | ANTIINFLAMMATORY AGENT, ANTIHISTAMINES, IMMUNOSUPPRESSION,AUTOIMMUNE DISEASES | SYNTEX U.S.A. INC. (US) | 1998-02-10 | — | — | US | disclosed |
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |