Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.52 |
| ▸ | NOS1 | P29475 | 2/20 | 0.52 |
| ▸ | NOS2 | P35228 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA7 | P43166 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 11/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8376056 | 0.91 | NOS3 (0.46) | NOS3NOS1NOS2CA1CA2 | |
| SCHEMBL5966652 | 0.86 | NOS3 (0.55) | NOS3NOS1NOS2MEN1GAA | |
| SCHEMBL2237559 | 0.86 | NOS3 (0.55) | NOS3NOS1NOS2MEN1GAA | |
| SCHEMBL29690693 | 0.81 | NOS3 (0.48) | NOS3NOS1NOS2CTSKPPARG | |
| SCHEMBL8939928 | 0.76 | NOS3 (0.54) | NOS3NOS1NOS2 | |
| SCHEMBL11024821 | 0.75 | NOS3 (0.42) | NOS3NOS1NOS2CTSKPPARG | |
| SCHEMBL5966544 | 0.75 | REN (0.49) | NOS3NOS1NOS2CTSKPPARG | |
| SCHEMBL7369114 | 0.74 | MEN1 (0.44) | CA1CA2CA7MEN1GAA | |
| SCHEMBL7399188 | 0.74 | CTSK (0.52) | CA1CA2CA7MEN1GAA | |
| SCHEMBL4820622 | 0.74 | CTSK (0.52) | CA1CA2CA7MEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0664786-B1 | ARGININE KETO-AMIDE ENZYME INHIBITORS | CORVAS INT INC (US) | 1999-03-24 | — | — | EP | disclosed |
| US-5869454-A | ANTICOAGULANTS | CORVAS INTERNATIONAL, INC. (US) | 1999-02-09 | — | — | US | disclosed |
| US-5670479-A | α-ketoamide derivatives as inhibitors of thrombosis | CORVAS INTERNATIONAL, INC. (US) | 1997-09-23 | — | — | US | disclosed |
| US-5656600-A | MODIFIED POLYPEPTIDES | CORVAS INTERNATIONAL, INC. (US) | 1997-08-12 | — | — | US | disclosed |
| US-5597804-A | ANTITHROMBOTIC AGENTS | CORVAS INTERNATIONAL, INC. (US) | 1997-01-28 | — | — | US | disclosed |
| EP-0693083-A4 | ALPHA-KETOAMIDE DERIVATIVES AS INHIBITORS OF THROMBOSIS | CORVAS INT INC (US) | 1996-07-17 | — | — | EP | disclosed |
| EP-0693083-A1 | ALPHA-KETOAMIDE DERIVATIVES AS INHIBITORS OF THROMBOSIS | CORVAS INTERNATIONAL, INC. (US) | 1996-01-24 | — | — | EP | disclosed |
| WO-1994021673-A1 | ALPHA-KETOAMIDE DERIVATIVES AS INHIBITORS OF THROMBOSIS | CORVAS INTERNATIONAL, INC. (US) | 1994-09-29 | — | — | WO | disclosed |