Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6121980 | 0.84 | ALDH1A1 (0.47) | ALDH1A1LMNAKMT2ATSHRCYP3A4 | |
| SCHEMBL630835 | 0.83 | ALDH1A1 (0.68) | ALDH1A1LMNAKMT2ACYP3A4MAPT | |
| SCHEMBL14775885 | 0.83 | TTR (0.50) | ALDH1A1LMNAKMT2ACYP3A4MAPT | |
| SCHEMBL31374314 | 0.83 | TTR (0.50) | ALDH1A1LMNAKMT2ACYP3A4MAPT | |
| SCHEMBL7095093 | 0.83 | ALDH1A1 (0.48) | ALDH1A1LMNAKMT2ATSHRCYP3A4 | |
| SCHEMBL8842559 | 0.81 | ALDH1A1 (0.47) | ALDH1A1LMNAKMT2ACYP3A4MAPT | |
| SCHEMBL11800281 | 0.79 | TSHR (0.62) | ALDH1A1LMNAKMT2ATSHRCYP3A4 | |
| SCHEMBL31218397 | 0.78 | LMNA (0.47) | ALDH1A1LMNAKMT2AMAPTPOLB | |
| SCHEMBL6896167 | 0.77 | HPGD (0.56) | ALDH1A1LMNAKMT2ATSHRCYP3A4 | |
| SCHEMBL30176207 | 0.77 | HPGD (0.56) | ALDH1A1LMNAKMT2ATSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1085871-A4 | QUINAZOLINONE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL MYERS SQUIBB CO (US) | 2001-10-04 | — | — | EP | disclosed |
| EP-1085871-A1 | QUINAZOLINONE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-03-28 | — | — | EP | disclosed |
| WO-1999064004-A1 | QUINAZOLINONE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-12-16 | — | — | WO | disclosed |