Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.39 |
| ▸ | CDC7 | O00311 | 5/20 | 0.39 |
| ▸ | CDK2 | P24941 | 5/20 | 0.39 |
| ▸ | PLK4 | O00444 | 4/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.39 |
| ▸ | INSR | P06213 | 4/20 | 0.39 |
| ▸ | CDK1 | P06493 | 4/20 | 0.39 |
| ▸ | PIM1 | P11309 | 4/20 | 0.39 |
| ▸ | PRKACA | P17612 | 4/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.39 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.39 |
| ▸ | CLK2 | P49760 | 4/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 4/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.39 |
| ▸ | STK3 | Q13188 | 4/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL787848 | 0.79 | GPR35 (0.47) | MAPK1KMT2AALDH1A1MEN1TSHR | |
| SCHEMBL8655624 | 0.78 | F10 (0.40) | GSK3BCDC7CDK2PLK4ROCK2 | |
| SCHEMBL11602617 | 0.77 | RAB9A (0.36) | GSK3BKMT2AALDH1A1MAPTHTT | |
| SCHEMBL7044916 | 0.76 | GPR35 (0.36) | GSK3BMAPK1KMT2AGPR35DAO | |
| SCHEMBL11603489 | 0.74 | GSK3B (0.55) | GSK3BMAPK1ALDH1A1 | |
| SCHEMBL11617019 | 0.72 | GSK3B (0.55) | GSK3BKMT2AALDH1A1MAPTMEN1 | |
| SCHEMBL14392386 | 0.69 | KDM4E (0.71) | MAPK1KMT2AALDH1A1MAPTNPSR1 | |
| SCHEMBL2225907 | 0.68 | — | — | |
| SCHEMBL7030961 | 0.67 | ALDH1A1 (0.46) | GSK3BCDC7CDK2PLK4ROCK2 | |
| SCHEMBL7039136 | 0.66 | GPR35 (0.40) | MAPK1KMT2AALDH1A1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| CN-1254335-A | Nicotinamide derivatives | PFIZER PROD INC (US) | 2000-05-24 | — | — | CN | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |