Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.35 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.33 |
| ▸ | CLK1 | P49759 | 4/20 | 0.33 |
| ▸ | CLK2 | P49760 | 4/20 | 0.33 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.33 |
| ▸ | MYLK | Q15746 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
| ▸ | CLK3 | P49761 | 1/20 | 0.32 |
| ▸ | DNM2 | P50570 | 2/20 | 0.32 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1519442 | 0.80 | LMNA (0.47) | DYRK1ACLK4CLK1CLK2DYRK1B | |
| SCHEMBL3320381 | 0.79 | KMT2A (0.46) | CLK4ALDH1A1SLC2A1 | |
| SCHEMBL11306815 | 0.77 | MKNK1 (0.50) | ALDH1A1 | |
| SCHEMBL8133400 | 0.77 | CXCR4 (0.54) | STK17AMRGPRX1DYRK1ACLK4CLK2 | |
| SCHEMBL16139311 | 0.77 | DNM2 (0.46) | MRGPRX1HRH4ALDH1A1DNM2 | |
| SCHEMBL10441707 | 0.76 | ATM (0.55) | ALDH1A1 | |
| SCHEMBL29836535 | 0.76 | ATM (0.55) | ALDH1A1 | |
| SCHEMBL9169741 | 0.76 | HRH4 (0.52) | HRH4 | |
| SCHEMBL1588726 | 0.76 | HRH4 (0.57) | HRH4 | |
| SCHEMBL14619914 | 0.74 | HRH4 (0.55) | STK17AHRH4DNM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1134412-C | N-substituted 2-cyanopyrodlidines | ��Ұ����ҩ��ʽ���� | 2004-01-14 | — | — | CN | disclosed |
| CN-1236361-A | N-substituted 2-cyanopyrrolidines | NOVARTIS AG (CH) | 1999-11-24 | — | — | CN | disclosed |
| EP-0937040-A2 | N-SUBSTITUTED 2-CYANOPYRROLIDINES | Novartis AG (CH) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998019998-A2 | N-SUBSTITUTED 2-CYANOPYRROLIDINES | NOVARTIS AG (CH) | 1998-05-14 | — | — | WO | disclosed |