Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 15/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.52 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14029983 | 0.80 | HRH4 (0.54) | HRH4HRH3NUDT1CHRNA7 | |
| SCHEMBL1519442 | 0.79 | LMNA (0.47) | HRH4 | |
| SCHEMBL16844971 | 0.79 | HRH4 (0.52) | HRH4HRH3NUDT1CHRNA7 | |
| SCHEMBL9086602 | 0.77 | IDH1 (0.42) | HRH4HRH3NUDT1MAPK8 | |
| SCHEMBL16139311 | 0.76 | DNM2 (0.46) | HRH4MAPK8 | |
| SCHEMBL14004971 | 0.76 | HRH4 (0.50) | HRH4HRH3NUDT1CHRNA7 | |
| SCHEMBL12933710 | 0.76 | HRH4 (0.50) | HRH4HRH3NUDT1CHRNA7 | |
| SCHEMBL12932877 | 0.76 | HRH4 (0.50) | HRH4HRH3NUDT1PLK1 | |
| SCHEMBL9169811 | 0.76 | SMN1; SMN2 (0.47) | PLK1 | |
| SCHEMBL7369640 | 0.76 | STK17A (0.35) | HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0644885-A1 | NOVEL BIOLOGICALLY ACTIVE EBURNAMENINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME | RICHETER GEDEON VEGYESZETI GYAR RT. (HU) | 1995-03-29 | — | — | EP | disclosed |