Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HMGB1 | P09429 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11897168 | 0.88 | FOLH1 (0.57) | FOLH1ALDH1A1ALOX15HMGB1TSHR | |
| SCHEMBL11897138 | 0.88 | FOLH1 (0.57) | FOLH1ALDH1A1ALOX15HMGB1TSHR | |
| SCHEMBL11897139 | 0.88 | FOLH1 (0.57) | FOLH1ALDH1A1ALOX15HMGB1TSHR | |
| SCHEMBL461025 | 0.85 | FOLH1 (0.50) | FOLH1ALDH1A1ALOX15HMGB1TSHR | |
| SCHEMBL6924561 | 0.85 | ALDH1A1 (0.44) | ALDH1A1TSHRLMNAHTTKDM4E | |
| SCHEMBL8671990 | 0.85 | FOLH1 (0.53) | FOLH1ALDH1A1ALOX15HMGB1TSHR | |
| SCHEMBL4041914 | 0.83 | FOLH1 (0.52) | FOLH1ALDH1A1ALOX15HMGB1TSHR | |
| SCHEMBL2831021 | 0.83 | HMGB1 (0.45) | FOLH1ALDH1A1ALOX15HMGB1CLCN2 | |
| SCHEMBL6361489 | 0.81 | FOLH1 (0.50) | FOLH1ALDH1A1ALOX15HMGB1TSHR | |
| SCHEMBL5830299 | 0.81 | FOLH1 (0.50) | FOLH1ALDH1A1ALOX15HMGB1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0695184-B1 | HIV PROTEASE INHIBITORS | AGOURON PHARMA (US) | 1999-04-21 | — | — | EP | disclosed |
| US-5863950-A | AMIDES OR THIO AMIDE COMPOUNDS WITH HYDROXY OR ETHER GROUPS | AGOURON PHARMACEUTICALS, INC. (US) | 1999-01-26 | — | — | US | disclosed |
| US-5714518-A | HIV protease inhibitors and methods of making the same | AGOURON PHARMACEUTICALS (US) | 1998-02-03 | — | — | US | disclosed |
| EP-0695184-A4 | HIV PROTEASE INHIBITORS | AGOURON PHARMA (US) | 1996-05-22 | — | — | EP | disclosed |
| EP-0695184-A1 | HIV PROTEASE INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 1996-02-07 | — | — | EP | disclosed |
| WO-1994015906-A1 | HIV PROTEASE INHIBITORS AND THEIR PREPARATION | AGOURON PHARMACEUTICALS, INC. (US) | 1994-07-21 | — | — | WO | disclosed |
| WO-1994015608-A1 | HIV PROTEASE INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 1994-07-21 | — | — | WO | disclosed |