Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.47 |
| ▸ | PDE4A | P27815 | 3/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369628 | 0.86 | LMNA (0.64) | LMNAMEN1KMT2ACYP1A2PDE3B | |
| SCHEMBL7362818 | 0.83 | PDE3B (0.49) | LMNAMEN1KMT2ACYP1A2PDE3B | |
| SCHEMBL10782022 | 0.80 | LMNA (0.64) | LMNAMEN1KMT2ACYP1A2PDE3B | |
| SCHEMBL3452908 | 0.77 | LMNA (0.80) | LMNAMEN1KMT2ACYP1A2PDE3B | |
| SCHEMBL1376637 | 0.74 | LMNA (1.00) | LMNAMEN1KMT2ACYP1A2PDE3B | |
| SCHEMBL10966762 | 0.74 | LMNA (0.61) | LMNAMEN1KMT2ACYP1A2PDE3B | |
| SCHEMBL10967581 | 0.74 | LMNA (0.69) | LMNAMEN1KMT2ACYP1A2PDE3B | |
| Hydrochloric Acid SCHEMBL30367906 | 0.73 | LMNA (0.59) | LMNAMEN1KMT2ACYP1A2PDE3B | |
| SCHEMBL14881124 | 0.72 | CASP3 (0.56) | LMNATP53MAPTNOTUM | |
| SCHEMBL4122238 | 0.72 | LMNA (0.67) | LMNAMEN1KMT2ACYP1A2PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4665074-A | CARDIOTONIC, BRONCHOSPASMOLYTIC | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1987-05-12 | — | — | US | claimed |
| US-4665074-A | CARDIOTONIC, BRONCHOSPASMOLYTIC | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1987-05-12 | — | — | US | disclosed |
| EP-0163965-A2 | Pyridazinones, their preparation and use, medicaments containing pyridazinones | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1985-12-11 | — | — | EP | disclosed |