Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.54 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.48 |
| ▸ | PDE4A | P27815 | 3/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369722 | 0.86 | LMNA (0.59) | LMNAMEN1KMT2ACYP1A2NOTUM | |
| SCHEMBL29151059 | 0.82 | XDH (0.59) | LMNAMEN1KMT2ACYP1A2PDE3B | |
| SCHEMBL30745160 | 0.82 | XDH (0.59) | LMNAMEN1KMT2ACYP1A2PDE3B | |
| SCHEMBL14881124 | 0.81 | CASP3 (0.56) | LMNANOTUMSCN5APOLBL3MBTL1 | |
| SCHEMBL3452908 | 0.80 | LMNA (0.80) | LMNAMEN1KMT2ACYP1A2HRH3 | |
| SCHEMBL1376637 | 0.78 | LMNA (1.00) | LMNAMEN1KMT2ACYP1A2NOTUM | |
| SCHEMBL10966762 | 0.78 | LMNA (0.61) | LMNAMEN1KMT2ACYP1A2NOTUM | |
| SCHEMBL13070912 | 0.78 | PDE4A (0.56) | LMNAMEN1KMT2ACYP1A2NOTUM | |
| SCHEMBL10782022 | 0.77 | LMNA (0.64) | LMNAMEN1KMT2ACYP1A2HRH3 | |
| SCHEMBL38652709 | 0.77 | PDE4A (0.55) | LMNAMEN1KMT2ACYP1A2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4665074-A | CARDIOTONIC, BRONCHOSPASMOLYTIC | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1987-05-12 | — | — | US | claimed |
| US-4665074-A | CARDIOTONIC, BRONCHOSPASMOLYTIC | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1987-05-12 | — | — | US | disclosed |
| EP-0163965-A2 | Pyridazinones, their preparation and use, medicaments containing pyridazinones | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 1985-12-11 | — | — | EP | disclosed |