Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367851 | 0.82 | LRRK2 (0.58) | MAPK1LMNAEGFRMEN1KMT2A | |
| SCHEMBL8548496 | 0.79 | ALDH1A1 (0.57) | MAOAMAOBEGFRALDH1A1MEN1 | |
| SCHEMBL8879157 | 0.78 | MAOB (0.53) | MAOAMAOBEGFRSMN1; SMN2MAPT | |
| SCHEMBL21449905 | 0.78 | AHR (0.49) | MAOAMAOBEGFRMAPTIDO1 | |
| SCHEMBL8542362 | 0.77 | EGFR (0.48) | MAOAMAOBEGFRALDH1A1 | |
| SCHEMBL16767959 | 0.76 | L3MBTL1 (0.60) | MAPK1LMNAKCNMA1ALDH1A1SMN1; SMN2 | |
| SCHEMBL17486820 | 0.75 | MEN1 (0.69) | MAPK1LMNAKCNMA1ALDH1A1ATM | |
| SCHEMBL14513874 | 0.75 | MAOB (0.51) | MAOAMAOBEGFRMAPTP2RX3 | |
| SCHEMBL9994875 | 0.74 | MAPK1 (0.60) | MAPK1LMNAKCNMA1ALDH1A1ATM | |
| SCHEMBL11948698 | 0.74 | HPGD (0.51) | MAPK1MAOAMAOBEGFRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1067386-C | 5-heteroarylindole derivatives as benzodiazepine receptor site agonists and analagonists | PFIZER (US) | 2001-06-20 | — | — | CN | disclosed |
| US-5688809-A | 5-heteroarylindole derivatives | PFIZER INC. (US) | 1997-11-18 | — | — | US | disclosed |
| CN-1142823-A | 5-heteroarylindole derivatives as benzodiazepine receptor site agonists and analagonists | PFIZER (US) | 1997-02-12 | — | — | CN | disclosed |
| WO-1995021836-A1 | 5-HETEROARYLINDOLE DERIVATIVES AS BENZODIAZEPINE RECEPTOR SITE AGONISTS AND ANTAGONISTS | PFIZER INC. (US) | 1995-08-17 | — | — | WO | disclosed |