Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.39 |
| ▸ | BCL6 | P41182 | 1/20 | 0.39 |
| ▸ | BCOR | Q6W2J9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8542362 | 0.90 | EGFR (0.48) | ALDH1A1HTTRAB9AGAAEGFR | |
| SCHEMBL7369825 | 0.79 | MAPK1 (0.49) | ALDH1A1EGFRMAPTMAOAMAOB | |
| SCHEMBL29706723 | 0.79 | ALDH1A1 (0.55) | ALDH1A1HTTRAB9AGAAMAPT | |
| SCHEMBL8548736 | 0.78 | FGFR2 (0.55) | EGFRFGFR2FLT3MAOAMAOB | |
| SCHEMBL21449905 | 0.77 | AHR (0.49) | RAB9AEGFRMAPTLRRK2MAOA | |
| SCHEMBL7367851 | 0.76 | LRRK2 (0.58) | RAB9AEGFRMAPTLRRK2MEN1 | |
| SCHEMBL2975973 | 0.76 | PRKCQ (0.55) | EGFRLRRK2FGFR2FLT3MAOA | |
| SCHEMBL16657362 | 0.76 | ALDH1A1 (0.60) | ALDH1A1HTTRAB9AGAAEGFR | |
| SCHEMBL8877814 | 0.76 | MAPT (0.54) | ALDH1A1RAB9AEGFRMAPTFGFR2 | |
| SCHEMBL8543006 | 0.76 | FGFR2 (0.55) | EGFRFGFR2FLT3MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4970219-A | TOPICAL ANTIINFLAMMATORY AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-11-13 | — | — | US | claimed |
| EP-0405425-B1 | Heteroarylamino- and heteroaryloxypyridinamines and related compounds, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1998-08-12 | — | — | EP | disclosed |
| US-5405856-A | Skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-04-11 | — | — | US | disclosed |
| US-5221682-A | Skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-06-22 | — | — | US | disclosed |
| US-5034403-A | Topical antiinflammatory agents for skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-07-23 | — | — | US | disclosed |
| US-4983615-A | ANTIINFLAMMATORY AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-01-08 | — | — | US | disclosed |
| EP-0405425-A2 | Heteroarylamino- and heteroaryloxypyridinamines and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-02 | — | — | EP | disclosed |
| US-4970219-A | TOPICAL ANTIINFLAMMATORY AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-11-13 | — | — | US | disclosed |