Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7371515 | 0.89 | ABCB1 (0.49) | ABCB1ALOX5MEN1LMNAKMT2A | |
| SCHEMBL7367400 | 0.82 | ALDH1A1 (0.47) | ABCB1MEN1KMT2AALDH1A1 | |
| SCHEMBL1460239 | 0.80 | ABCB1 (0.53) | ABCB1MEN1KMT2AALDH1A1CTSL | |
| SCHEMBL8276259 | 0.79 | ABCB1 (0.56) | ABCB1LMNAKMT2AALDH1A1CTSL | |
| SCHEMBL21952369 | 0.79 | ABCB1 (0.44) | ABCB1MEN1LMNAKMT2AALDH1A1 | |
| SCHEMBL20004309 | 0.79 | ALDH1A1 (0.50) | ALOX5MEN1LMNAKMT2AALDH1A1 | |
| SCHEMBL5149951 | 0.78 | ABCB1 (0.58) | ABCB1LMNAKMT2AALDH1A1CTSL | |
| SCHEMBL19754815 | 0.78 | ABCB1 (0.49) | ABCB1ALOX5MEN1LMNAKMT2A | |
| SCHEMBL23220190 | 0.77 | ABCB1 (0.42) | ABCB1MEN1LMNAKMT2AALDH1A1 | |
| SCHEMBL30191411 | 0.77 | ABCB1 (0.51) | ABCB1KMT2AALDH1A1CTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952321-A | Substituted azetidinones as anti-inflammatory and antidegenerative agents | MERCK & CO., INC. (US) | 1999-09-14 | — | — | US | disclosed |
| EP-0666846-A4 | — | — | 1995-09-20 | — | — | EP | disclosed |
| EP-0666846-A1 | NEW SUBSTITUTED AZETIDINONES AS ANTI-INFLAMMATORY AND ANTIDEGENERATIVE AGENTS | MERCK & CO. INC. (US) | 1995-08-16 | — | — | EP | disclosed |
| WO-1994010143-A1 | NEW SUBSTITUTED AZETIDINONES AS ANTI-INFLAMMATORY AND ANTIDEGENERATIVE AGENTS | MERCK & CO., INC. (US) | 1994-05-11 | — | — | WO | disclosed |