Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 2/20 | 0.45 |
| ▸ | CTSB | P07858 | 2/20 | 0.45 |
| ▸ | CTSS | P25774 | 2/20 | 0.45 |
| ▸ | CTSK | P43235 | 2/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.44 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.44 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8276259 | 0.87 | ABCB1 (0.56) | ABCB1ALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL20426017 | 0.86 | ABCB1 (0.52) | ABCB1ALDH1A1MAPTHPGDSLC15A1 | |
| SCHEMBL5149951 | 0.85 | ABCB1 (0.58) | ABCB1ALDH1A1MAPTHPGDKMT2A | |
| SCHEMBL30191411 | 0.84 | ABCB1 (0.51) | ABCB1ALDH1A1MAPTHPGDSLC15A1 | |
| SCHEMBL9024593 | 0.84 | ABCB1 (0.51) | ABCB1ALDH1A1MAPTHPGDSLC15A1 | |
| SCHEMBL25100442 | 0.84 | ABCB1 (0.53) | ABCB1ALDH1A1MAPTHPGDSLC15A1 | |
| SCHEMBL381082 | 0.84 | ABCB1 (0.53) | ABCB1ALDH1A1MAPTHPGDSLC15A1 | |
| SCHEMBL381080 | 0.84 | ABCB1 (0.53) | ABCB1ALDH1A1MAPTHPGDSLC15A1 | |
| SCHEMBL7404261 | 0.84 | ABCB1 (0.53) | ABCB1ALDH1A1MAPTHPGDSLC15A1 | |
| SCHEMBL8697935 | 0.84 | ABCB1 (0.53) | ABCB1ALDH1A1MAPTHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4628499-A1 | POLYPEPTIDE INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Hansoh Biomedical Co., Ltd. (CN) | 2025-10-08 | — | — | EP | disclosed |
| EP-2683394-B1 | ACTIVE AGENT PRODRUGS WITH HETEROCYCLIC LINKERS | SIGNATURE THERAPEUTICS INC (US) | 2021-01-06 | — | — | EP | disclosed |
| CN-103813800-B | Active agent prodrugs with heterocyclic linkers | 特色疗法股份有限公司 | 2017-12-19 | — | — | CN | disclosed |
| US-9499581-B2 | Compositions comprising enzyme-cleavable oxycodone prodrug | SIGNATURE THERAPEUTICS, INC. (US) | 2016-11-22 | — | — | US | disclosed |
| CN-102695545-B | Compositions comprising enzymatically cleavable ketone-modified opioid prodrugs and optional inhibitors thereof | 特色疗法股份有限公司 | 2016-08-17 | — | — | CN | disclosed |
| EP-2663187-B1 | COMPOSITIONS COMPRISING ENZYME-CLEAVABLE OXYCODONE PRODRUG | SIGNATURE THERAPEUTICS INC (US) | 2016-06-01 | — | — | EP | disclosed |
| CN-103384472-B | Comprise the composition of the Oxycodone prodrug of enzyme cleavable | SIGNATURE THERAPEUTICS, INC. (US) | 2016-01-20 | — | — | CN | disclosed |
| US-20160002291-A1 | Active Agent Prodrugs with Heterocyclic Linkers | SIGNATURE THERAPEUTICS INC (US) | 2016-01-07 | — | — | US | disclosed |
| US-9139612-B2 | Active agent prodrugs with heterocyclic linkers | SIGNATURE THERAPEUTICS, INC. (US) | 2015-09-22 | — | — | US | disclosed |
| US-9095627-B2 | Opioid prodrugs with heterocyclic linkers | SIGNATURE THERAPEUTICS, INC. (US) | 2015-08-04 | — | — | US | disclosed |
| WO-2012122412-A2 | COMPOSITIONS FOR REDUCING RISK OF ADVERSE EVENTS CAUSED BY DRUG-DRUG INTERACTIONS | SIGNATURE THERAPEUTICS, INC. (US) | 2012-09-13 | — | — | WO | disclosed |
| WO-2012096887-A2 | COMPOSITIONS COMPRISING ENZYME-CLEAVABLE OXYCODONE PRODRUG | SIGNATURE THERAPEUTICS, INC. (US) | 2012-07-19 | — | — | WO | disclosed |
| WO-2012096886-A1 | COMPOSITIONS COMPRISING ENZYME-CLEAVABLE OXYCODONE PRODRUG | SIGNATURE THERAPEUTICS, INC. (US) | 2012-07-19 | — | — | WO | disclosed |
| US-20120178772-A1 | Compositions Comprising Enzyme-Cleavable Oxycodone Prodrug | 3I, LP | 2012-07-12 | — | — | US | disclosed |
| US-20120178773-A1 | Compositions Comprising Enzyme-Cleavable Oxycodone Prodrug | 3I, LP | 2012-07-12 | — | — | US | disclosed |
| WO-2011133149-A1 | COMPOSITIONS COMPRISING ENZYME-CLEAVABLE OPIOID PRODRUGS AND INHIBITORS THEREOF | PHARMACOFORE, INC. (US) | 2011-10-27 | — | — | WO | disclosed |
| WO-2011133150-A1 | COMPOSITIONS COMPRISING ENZYME-CLEAVABLE PRODRUGS OF ACTIVE AGENTS AND INHIBITORS THEREOF | PHARMACOFORE, INC. (US) | 2011-10-27 | — | — | WO | disclosed |
| US-20110262355-A1 | COMPOSITIONS COMPRISING ENZYME-CLEAVABLE OPIOID PRODRUGS AND INHIBITORS THEREOF | SIGNATURE THERAPEUTICS, INC. | 2011-10-27 | — | — | US | disclosed |
| US-20110262359-A1 | COMPOSITIONS COMPRISING ENZYME-CLEAVABLE PRODRUGS OF ACTIVE AGENTS AND INHIBITORS THEREOF | SIGNATURE THERAPEUTICS, INC. | 2011-10-27 | — | — | US | disclosed |
| WO-2011031350-A1 | COMPOSITIONS COMPRISING ENZYME-CLEAVABLE KETONE-MODIFIED OPIOID PRODRUGS AND OPTIONAL INHIBITORS THEREOF | PHARMACOFORE, INC. (US) | 2011-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110262359-A1 | COMPOSITIONS COMPRISING ENZYME-CLEAVABLE PRODRUGS OF ACTIVE AGENTS AND INHIBITORS THEREOF | PEPD, TMPRSS15, ADAM17 | ABCB1 302/4885ALDH1A1 982/4885MAPT 2944/4885 |
| US-20120178773-A1 | Compositions Comprising Enzyme-Cleavable Oxycodone Prodrug | OPRK1, CYP3A7, OPRD1 | ABCB1 627/4885ALDH1A1 3371/4885MAPT 3948/4885 |
| US-20160002291-A1 | Active Agent Prodrugs with Heterocyclic Linkers | PEPD, SI, PREP | ABCB1 1391/4885ALDH1A1 1956/4885MAPT 4417/4885 |
| US-20110262355-A1 | COMPOSITIONS COMPRISING ENZYME-CLEAVABLE OPIOID PRODRUGS AND INHIBITORS THEREOF | ACHE, OPRM1, DNPEP | ABCB1 584/4885ALDH1A1 470/4885MAPT 1589/4885 |
| US-20120178772-A1 | Compositions Comprising Enzyme-Cleavable Oxycodone Prodrug | OPRK1, KDM8, ADAM8 | ABCB1 865/4885ALDH1A1 2596/4885MAPT 3401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.