Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.52 |
| ▸ | UGCG | Q16739 | 5/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.45 |
| ▸ | PREP | P48147 | 3/20 | 0.45 |
| ▸ | FAP | Q12884 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8476331 | 1.00 | MAPK8 (0.52) | MAPK8UGCGPOLBALDH1A1LMNA | |
| SCHEMBL7363975 | 0.86 | CYP2C19 (0.52) | POLBALDH1A1LMNAACEKCNK3 | |
| SCHEMBL7361372 | 0.85 | ACE (0.45) | ALDH1A1LMNAACEKCNK3PREP | |
| SCHEMBL7364635 | 0.85 | ALDH1A1 (0.47) | ALDH1A1LMNAACEKCNK3PREP | |
| SCHEMBL7368109 | 0.84 | PREP (0.43) | POLBALDH1A1LMNAACEKCNK3 | |
| SCHEMBL7366700 | 0.84 | ACE (0.50) | POLBALDH1A1LMNAACEPREP | |
| SCHEMBL8720975 | 0.78 | ACE (0.45) | ALDH1A1LMNAACEKCNK3PREP | |
| SCHEMBL7369394 | 0.78 | SMYD3 (0.50) | ALDH1A1LMNAACEKCNK3PREP | |
| SCHEMBL7368017 | 0.77 | ACE (0.47) | ALDH1A1LMNAACEKCNK3PREP | |
| SCHEMBL7366766 | 0.75 | PREP (0.66) | ALDH1A1LMNAACEKCNK3PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0500989-B1 | N-(alpha-substituted-pyridinyl) carbonyl dipeptide antihypertensive agents | LACER SA (ES) | 1998-12-09 | — | — | EP | disclosed |
| US-5432159-A | N-(α-substituted-pyridinyl)carbonyl dipeptide antihypertensive agents | LACER S.A. (ES) | 1995-07-11 | — | — | US | disclosed |
| WO-1992015608-A1 | N-(α-SUBSTITUTED-PYRIDINYL)CARBONYL DIPEPTIDE ANTIHYPERTENSIVE AGENTS | LACER S.A. (ES) | 1992-09-17 | — | — | WO | disclosed |
| EP-0500989-A1 | N-(alpha-substituted-pyridinyl) carbonyl dipeptide antihypertensive agents | LACER, S.A. (ES) | 1992-09-02 | — | — | EP | disclosed |