Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | TTK | P33981 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
| ▸ | CLK3 | P49761 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TOP1 | P11387 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367420 | 0.91 | DYRK1A (0.49) | PDE4APDE4BPDE4CPDE4DDYRK1A | |
| SCHEMBL2887372 | 0.86 | KDM4E (0.54) | PDE4APDE4BPDE4CPDE4DDYRK1A | |
| SCHEMBL7365583 | 0.81 | MAPK1 (0.55) | PDE4APDE4BPDE4CPDE4DTTK | |
| SCHEMBL7370628 | 0.81 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4DGAA | |
| SCHEMBL1249841 | 0.81 | AURKA (0.54) | PDE4APDE4BPDE4CPDE4DGAA | |
| SCHEMBL7366347 | 0.81 | PARP1 (0.46) | PDE4APDE4BPDE4CPDE4DDYRK1A | |
| SCHEMBL4838570 | 0.80 | ENPP1 (0.56) | PDE4APDE4BPDE4CPDE4DDYRK1A | |
| SCHEMBL1252689 | 0.80 | PARP1 (0.43) | PDE4APDE4BPDE4CPDE4DTTK | |
| SCHEMBL1251253 | 0.80 | NPSR1 (0.67) | TTKGAAALDH1A1KDM4ENPC1 | |
| SCHEMBL9169239 | 0.78 | PIM1 (0.55) | NOTUMALDH1A1KDM4EGRM4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |