Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.44 |
| ▸ | FER | P16591 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | MARK3 | P27448 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.44 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.44 |
| ▸ | STK3 | Q13188 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363947 | 0.90 | DCLK1 (0.46) | PARP1NPSR1ATMDCLK1PRKD3 | |
| SCHEMBL7370628 | 0.84 | PDE4A (0.52) | PARP1NPSR1ATMTDO2KDM4E | |
| SCHEMBL1249841 | 0.84 | AURKA (0.54) | PARP1NPSR1ATMMAP4K4FLT3 | |
| SCHEMBL1251253 | 0.83 | NPSR1 (0.67) | PARP1NPSR1ATMIDO1KDM4E | |
| SCHEMBL7370355 | 0.81 | PDE4A (0.48) | CLK2DYRK1ACLK4KDM4ENPC1 | |
| SCHEMBL1252689 | 0.81 | PARP1 (0.43) | PARP1NPSR1ATMKDM4EALDH1A1 | |
| SCHEMBL9169239 | 0.81 | PIM1 (0.55) | PARP1NPSR1ATMTDO2KDM4E | |
| SCHEMBL7362871 | 0.80 | PDE4D (0.57) | IDO1MAPTLMNAPDE4APDE4B | |
| SCHEMBL1252788 | 0.79 | IDO1 (0.55) | PARP1NPSR1ATMCLK2DYRK1A | |
| SCHEMBL1251585 | 0.79 | NPSR1 (0.51) | PARP1NPSR1ATMKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |