Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RORB | Q92753 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7361843 | 0.90 | PDE4A (0.50) | PDE4APDE4CPDE4DPDE4BPDE3B | |
| SCHEMBL1249841 | 0.84 | AURKA (0.54) | PDE4APDE4CPDE4DPDE4BPDE3B | |
| SCHEMBL7366347 | 0.84 | PARP1 (0.46) | PDE4APDE4CPDE4DPDE4BPARP1 | |
| SCHEMBL1251253 | 0.83 | NPSR1 (0.67) | PARP1ALDH1A1SMN1; SMN2ATMNPSR1 | |
| SCHEMBL1788378 | 0.83 | NPSR1 (0.67) | PDE4APDE4CPDE4DPDE4BALDH1A1 | |
| SCHEMBL7370355 | 0.81 | PDE4A (0.48) | PDE4APDE4CPDE4DPDE4BALDH1A1 | |
| SCHEMBL1252689 | 0.81 | PARP1 (0.43) | PDE4APDE4CPDE4DPDE4BPARP1 | |
| SCHEMBL9169239 | 0.81 | PIM1 (0.55) | PARP1ALDH1A1LMNASMN1; SMN2ATM | |
| SCHEMBL7362871 | 0.80 | PDE4D (0.57) | PDE4APDE4CPDE4DPDE4BLMNA | |
| SCHEMBL1252788 | 0.79 | IDO1 (0.55) | PARP1ATMNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612321-B1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX INC (US) | 1999-08-25 | — | — | EP | disclosed |
| EP-0612321-A1 | PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993007146-A1 | BENZO AND PYRIDO PYRIDAZINONE AND PYRIDAZINTHIONE COMPOUNDS WITH PDE IV INHIBITING ACTIVITY | SYNTEX (U.S.A.) INC. (US) | 1993-04-15 | — | — | WO | disclosed |