Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | BCL9 | O00512 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370462 | 0.82 | HTR2A (0.51) | HTR2AALDH1A1SMN1; SMN2MGLLNPC1 | |
| SCHEMBL7418355 | 0.75 | HTR2A (0.57) | HTR2AALDH1A1SMN1; SMN2KMT2ANPC1 | |
| SCHEMBL29592309 | 0.74 | HTR2A (0.62) | HTR2AALDH1A1SMN1; SMN2KMT2ANPC1 | |
| SCHEMBL6443753 | 0.74 | MGLL (0.54) | HTR2AALDH1A1SMN1; SMN2MGLLKMT2A | |
| SCHEMBL8818613 | 0.73 | ALDH1A1 (0.52) | HTR2AALDH1A1SMN1; SMN2MGLLKMT2A | |
| SCHEMBL21570247 | 0.73 | ALDH1A1 (0.52) | HTR2AALDH1A1SMN1; SMN2MGLLKMT2A | |
| SCHEMBL389680 | 0.73 | ALDH1A1 (0.52) | HTR2AALDH1A1SMN1; SMN2MGLLKMT2A | |
| SCHEMBL1714950 | 0.73 | HTR2A (0.70) | HTR2AALDH1A1SMN1; SMN2KMT2ANPC1 | |
| SCHEMBL4644851 | 0.72 | HTR2A (0.56) | HTR2AALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8817429 | 0.72 | ALDH1A1 (0.53) | HTR2AALDH1A1SMN1; SMN2MGLLKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5907068-A | TRIFLUOROMETHYLSUBSTITUTED COMPOUND INCLUDED IN PEPTIDES | ZENECA INC. (US) | 1999-05-25 | — | — | US | disclosed |
| US-5726158-A | INHIBITORS OF HUMAN LEUKOCYTE ELASTASE USEFUL IN TREATING TISSUE DEGENERATIVE DISEASES; TRIFLUOROMETHYL KETONE SUBSTITUTED DI-, TRI-, AND TETRA-PEPTIDE DERIVATIVES | ZENECA INC. (US) | 1998-03-10 | — | — | US | disclosed |
| US-5414132-A | Peptide intermediates | ZENECA INC. (US) | 1995-05-09 | — | — | US | disclosed |
| US-5194588-A | Inhibitors of human leukocyte elastase, di-, tri- and tetra-peptides | ICI AMERICAS INC. (US) | 1993-03-16 | — | — | US | disclosed |
| EP-0189305-B1 | PEPTIDE DERIVATIVES | ICI AMERICAS INC. (US) | 1992-07-29 | — | — | EP | disclosed |