Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.35 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | SFRP1 | Q8N474 | 3/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7371245 | 0.89 | SMN1; SMN2 (0.39) | PLAUPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL7373053 | 0.87 | ALDH1A1 (0.45) | PLAUPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL6433528 | 0.87 | ALDH1A1 (0.45) | PLAUPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL7590429 | 0.87 | ALDH1A1 (0.45) | PLAUPIK3CDPIK3CAPIK3CBPIK3CG | |
| Hydrochloric Acid SCHEMBL6433791 | 0.86 | ALDH1A1 (0.44) | PLAUPIK3CDPIK3CAPIK3CBPIK3CG | |
| Hydrochloric Acid SCHEMBL6434299 | 0.86 | ALDH1A1 (0.44) | PLAUPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL7370515 | 0.82 | PLAU (0.37) | PLAUPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL6434837 | 0.80 | PLAU (0.37) | PLAUALDH1A1KDM4E | |
| SCHEMBL6965041 | 0.79 | F2 (0.35) | PLAUALDH1A1KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL6432755 | 0.79 | F2 (0.35) | PLAUALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |