Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.36 |
| ▸ | IDH2 | P48735 | 3/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.35 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | STK25 | O00506 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7371248 | 0.89 | SMN1; SMN2 (0.41) | PLAUIDH2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL7590438 | 0.87 | ALDH1A1 (0.45) | PLAUIDH2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL7373058 | 0.87 | ALDH1A1 (0.45) | PLAUIDH2PIK3CDPIK3CAPIK3CB | |
| Hydrochloric Acid SCHEMBL7366884 | 0.86 | ALDH1A1 (0.44) | PLAUIDH2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL7370512 | 0.82 | PLAU (0.35) | PLAUPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL7366260 | 0.80 | PLAU (0.39) | PLAUPDK1PDK2PDK3PDK4 | |
| SCHEMBL7374254 | 0.80 | CASP3 (0.50) | PLAU | |
| SCHEMBL7371376 | 0.80 | CASP3 (0.50) | PLAU | |
| SCHEMBL7050306 | 0.79 | PLAU (0.37) | PLAUPDK1PDK2PDK3PDK4 | |
| SCHEMBL7367638 | 0.78 | S1PR1 (0.40) | PLAUPDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077945-A1 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-2000005214-A2 | ISOQUINOLINES AS UROKINASE INHIBITORS | PFIZER INC. (US) | 2000-02-03 | — | — | WO | disclosed |