Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.36 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.35 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7373053 | 1.00 | ALDH1A1 (0.45) | ALDH1A1PLAUBRAFPIK3CDPIK3CA | |
| SCHEMBL6433528 | 1.00 | ALDH1A1 (0.45) | ALDH1A1PLAUBRAFPIK3CDPIK3CA | |
| Hydrochloric Acid SCHEMBL6433791 | 0.99 | ALDH1A1 (0.44) | ALDH1A1PLAUBRAFPIK3CDPIK3CA | |
| Hydrochloric Acid SCHEMBL6434299 | 0.99 | ALDH1A1 (0.44) | ALDH1A1PLAUBRAFPIK3CDPIK3CA | |
| SCHEMBL7371245 | 0.87 | SMN1; SMN2 (0.39) | ALDH1A1PLAUPIK3CDPIK3CAPIK3CB | |
| SCHEMBL7370512 | 0.87 | PLAU (0.35) | ALDH1A1PLAUBRAFPIK3CDPIK3CA | |
| SCHEMBL6435150 | 0.84 | ADAM17 (0.37) | ALDH1A1PLAUTDP1LMNA | |
| SCHEMBL7378281 | 0.84 | ADAM17 (0.37) | ALDH1A1PLAUTDP1LMNA | |
| SCHEMBL6434675 | 0.84 | ADAM17 (0.37) | ALDH1A1PLAUTDP1LMNA | |
| Hydrochloric Acid SCHEMBL6433470 | 0.83 | ADAM17 (0.36) | ALDH1A1PLAUTDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242120-A2 | COMBINATIONS OF GROWTH FACTORS AND I:UPA OR I:MMP FOR THE TREATMENT OF DAMAGED TISSUE | Pfizer Limited (GB) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001049309-A2 | COMBINATIONS OF GROWTH FACTORS AND I: UPA OR I: MMP FOR THE TREATMENT OF DAMAGED TISSUE | PFIZER LIMITED (GB) | 2001-07-12 | — | — | WO | disclosed |