Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.47 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367980 | 0.84 | KMT2A (0.54) | MAPK8TDP1 | |
| SCHEMBL7368640 | 0.78 | ALDH1A1 (0.54) | MAPK8TDP1ALDH1A1TBXAS1 | |
| SCHEMBL5216488 | 0.77 | TDP1 (0.56) | MAPK8TDP1ALDH1A1LMNA | |
| SCHEMBL7677170 | 0.77 | MAPK8 (0.54) | MAPK8TDP1ALDH1A1 | |
| SCHEMBL7694995 | 0.76 | TDP1 (0.55) | MAPK8TDP1ALDH1A1LMNA | |
| SCHEMBL13687413 | 0.76 | TDP1 (0.67) | MAPK8TDP1ALDH1A1 | |
| SCHEMBL7405287 | 0.76 | MAPK8 (0.64) | MAPK8TDP1ALDH1A1 | |
| SCHEMBL7401999 | 0.74 | MAPK8 (0.55) | MAPK8TDP1ALDH1A1 | |
| SCHEMBL7371975 | 0.74 | NAPRT (0.53) | ALDH1A1LMNATBXAS1 | |
| SCHEMBL7371084 | 0.74 | MAPK8 (0.58) | MAPK8TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |