Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | UGCG | Q16739 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370595 | 0.84 | MAPK8 (0.50) | MAPK8TDP1 | |
| SCHEMBL7371142 | 0.80 | KMT2A (0.59) | KMT2AMAPK8TDP1 | |
| SCHEMBL7371975 | 0.79 | NAPRT (0.53) | — | |
| SCHEMBL7367287 | 0.78 | KMT2A (0.47) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7369264 | 0.78 | KMT2A (0.50) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7369624 | 0.78 | KMT2A (0.57) | KMT2AMAPK8TDP1 | |
| SCHEMBL2779361 | 0.77 | KMT2A (0.65) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7373608 | 0.77 | KMT2A (0.54) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7405328 | 0.76 | MAPK8 (0.55) | KMT2APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7674701 | 0.76 | KMT2A (0.64) | KMT2APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |