Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.36 |
| ▸ | BACE1 | P56817 | 3/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7371375 | 0.97 | TSHR (0.41) | TDP1TSHRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4912359 | 0.94 | TDP1 (0.46) | TDP1TSHRSMN1; SMN2BACE1KCNH2 | |
| SCHEMBL7368751 | 0.92 | CA1 (0.46) | TDP1TSHRNPC1RAB9ACYP2D6 | |
| SCHEMBL7378250 | 0.89 | CA1 (0.46) | TDP1TSHRNPC1RAB9ACYP2D6 | |
| SCHEMBL7376546 | 0.85 | CA2 (0.49) | TDP1FAAHCA1CA2MMP1 | |
| SCHEMBL7374314 | 0.81 | TDP1 (0.39) | TDP1TSHRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7377886 | 0.78 | CYP2D6 (0.39) | TDP1TSHRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8424725 | 0.77 | CA1 (0.42) | TDP1TSHRSMN1; SMN2FAAHCA1 | |
| SCHEMBL8426469 | 0.77 | ALDH1A1 (0.37) | TSHRHPGDEPHX1MMP1MMP2 | |
| SCHEMBL7377935 | 0.75 | TDP1 (0.44) | TDP1CYP2D6EPHX1BACE1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102752-A1 | SUCCINOYLAMINO LACTAMS AS INHIBITORS OF A BETA PROTEIN PRODUCTION | Du Pont Pharmaceuticals Company (US) | 2001-05-30 | — | — | EP | claimed |
| WO-2000007995-A1 | SUCCINOYLAMINO LACTAMS AS INHIBITORS OF Aβ PROTEIN PRODUCTION | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-02-17 | — | — | WO | claimed |
| EP-1102752-A1 | SUCCINOYLAMINO LACTAMS AS INHIBITORS OF A BETA PROTEIN PRODUCTION | Du Pont Pharmaceuticals Company (US) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007995-A1 | SUCCINOYLAMINO LACTAMS AS INHIBITORS OF Aβ PROTEIN PRODUCTION | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-02-17 | — | — | WO | disclosed |