Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.56 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | DHFR | P00374 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.47 |
| ▸ | TNF | P01375 | 2/20 | 0.47 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.46 |
| ▸ | TUBB | P07437 | 2/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.46 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.46 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.46 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.46 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.46 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.46 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.46 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.46 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16334606 | 0.95 | FDPS (0.51) | PDE4APDE4BPDE4CPDE4DPTPN1 | |
| SCHEMBL3965845 | 0.90 | FDPS (0.49) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL16607418 | 0.84 | MEN1 (0.43) | PDE4APDE4BPDE4CPDE4DPTPN1 | |
| SCHEMBL24384207 | 0.84 | MEN1 (0.46) | PDE4APDE4BPDE4CPDE4DDHFR | |
| SCHEMBL13215272 | 0.84 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DDHFR | |
| SCHEMBL17821696 | 0.83 | FDPS (0.58) | PDE4APDE4BPDE4CPDE4DDHFR | |
| SCHEMBL5550248 | 0.83 | PTGDR2 (0.57) | PDE4APDE4BPDE4CPDE4DPTPN1 | |
| SCHEMBL4506605 | 0.82 | CYP4F2 (0.48) | TNFALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL27921658 | 0.81 | LMNA (0.59) | PDE4APDE4BPDE4CPDE4DPTPN1 | |
| SCHEMBL24384026 | 0.81 | CCR5 (0.49) | PDE4APDE4BPDE4CPDE4DPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814651-A | PHOSPHODIESTERASE TYPE FOUR INHIBITORS | PFIZER INC. (US) | 1998-09-29 | — | — | US | disclosed |
| US-5563143-A | ANTIINFLAMMATORY AGENTS, AUTOIMMUNE DISORDERS | PFIZER INC. (US) | 1996-10-08 | — | — | US | disclosed |
| EP-0706795-A2 | Catechol diether compounds as inhibitors of TNF release | PFIZER INC. (US) | 1996-04-17 | — | — | EP | disclosed |
| EP-0672031-A1 | CATECHOL DIETHERS AS SELECTIVE PDE IV? INHIBITORS | PFIZER INC. (US) | 1995-09-20 | — | — | EP | disclosed |
| WO-1994012461-A1 | CATECHOL DIETHERS AS SELECTIVE PDEIV INHIBITORS | PFIZER INC. (US) | 1994-06-09 | — | — | WO | disclosed |