Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.66 |
| ▸ | KDR | P35968 | 2/20 | 0.51 |
| ▸ | AHR | P35869 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10656794 | 0.82 | GPR84 (0.64) | GPR84KDRAHRALDH1A1MAPK1 | |
| SCHEMBL28204348 | 0.82 | GPR84 (0.64) | GPR84KDRAHRALDH1A1MAPK1 | |
| SCHEMBL2028344 | 0.81 | GPR84 (1.00) | GPR84AHRALDH1A1MAPK1PBRM1 | |
| SCHEMBL8531453 | 0.80 | GPR84 (0.77) | GPR84AHRALDH1A1MAPK1PBRM1 | |
| SCHEMBL21438815 | 0.80 | GPR84 (0.71) | GPR84AHRALDH1A1MAPK1PBRM1 | |
| SCHEMBL31651424 | 0.80 | GPR84 (0.77) | GPR84AHRALDH1A1MAPK1PBRM1 | |
| SCHEMBL27612856 | 0.79 | NAPRT (0.73) | ALDH1A1NAPRTTP53SMN1; SMN2NPSR1 | |
| SCHEMBL10654486 | 0.79 | GPR84 (0.59) | GPR84KDRAHRALDH1A1MAPK1 | |
| SCHEMBL10521630 | 0.78 | GPR84 (0.67) | GPR84AHRALDH1A1MAPK1PBRM1 | |
| SCHEMBL31711506 | 0.78 | GPR84 (0.67) | GPR84AHRALDH1A1MAPK1PBRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |