Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 6/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.51 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.51 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 10/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 9/20 | 0.49 |
| ▸ | CYP17A1 | P05093 | 5/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370568 | 0.87 | CYP3A4 (0.55) | CYP3A4CYP1A2CYP1A1CYP1B1CYP11B2 | |
| SCHEMBL7371552 | 0.82 | CYP11B1 (0.49) | CYP3A4CYP1A2CYP1A1CYP1B1CYP11B2 | |
| SCHEMBL7369606 | 0.82 | NPC1 (0.49) | MKNK1MKNK2NPC1HSD17B10KDM4E | |
| SCHEMBL7372635 | 0.78 | CYP11B2 (0.52) | CYP3A4CYP1A2CYP1A1CYP1B1CYP11B2 | |
| SCHEMBL7370931 | 0.77 | CYP11B1 (0.51) | CYP3A4CYP1A2CYP1A1CYP1B1CYP11B2 | |
| SCHEMBL7370838 | 0.77 | MKNK1 (0.46) | CYP3A4CYP1A2CYP1A1CYP1B1CYP11B2 | |
| SCHEMBL7372273 | 0.76 | MKNK1 (0.43) | CYP3A4CYP1A2CYP1A1CYP1B1CYP11B2 | |
| SCHEMBL7372122 | 0.75 | CYP11B1 (0.46) | CYP3A4CYP1A2CYP1A1CYP1B1CYP11B2 | |
| SCHEMBL7371766 | 0.74 | PDE2A (0.53) | CYP3A4CYP1A2CYP1A1CYP1B1CYP11B2 | |
| SCHEMBL7370764 | 0.74 | KDM4E (0.48) | CYP3A4CYP1A2CYP1A1CYP1B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4822805-A | ANTIINFLAMMATORY AGENTS, CARDIOTONIC AGENTS, ANTIPLATELET AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-18 | — | — | US | disclosed |
| EP-0257897-A1 | Imidazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-02 | — | — | EP | disclosed |