Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KLK3 | P07288 | 2/20 | 0.47 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.47 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7370741 | 0.86 | MAPT (0.54) | NPC1SMN1; SMN2RAB9AMAPTKDM4E | |
| SCHEMBL7370785 | 0.82 | CYP3A4 (0.51) | NPC1RAB9AKDM4EHSD17B10MKNK1 | |
| SCHEMBL7373609 | 0.77 | MAPT (0.44) | NPC1SMN1; SMN2RAB9AMAPTKDM4E | |
| SCHEMBL7372230 | 0.77 | FYN (0.50) | NPC1SMN1; SMN2RAB9AMAPTKDM4E | |
| SCHEMBL7367019 | 0.77 | PDE2A (0.43) | NPC1SMN1; SMN2RAB9AMAPTKDM4E | |
| SCHEMBL7370295 | 0.74 | POLB (0.52) | SMN1; SMN2KDM4EHSD17B10MAPK1PDGFRB | |
| SCHEMBL11342031 | 0.73 | KDM4E (0.70) | NPC1SMN1; SMN2RAB9AMAPTKDM4E | |
| SCHEMBL30196133 | 0.73 | KDM4E (0.70) | NPC1SMN1; SMN2RAB9AMAPTKDM4E | |
| SCHEMBL7370361 | 0.73 | TLR8 (0.59) | NPC1SMN1; SMN2RAB9AMAPTKDM4E | |
| SCHEMBL7370764 | 0.72 | KDM4E (0.48) | NPC1SMN1; SMN2RAB9AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4822805-A | ANTIINFLAMMATORY AGENTS, CARDIOTONIC AGENTS, ANTIPLATELET AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-18 | — | — | US | disclosed |
| EP-0257897-A1 | Imidazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-02 | — | — | EP | disclosed |