Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | FAAH | O00519 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8487156 | 0.92 | POLB (0.44) | SIGMAR1KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL7377176 | 0.79 | SIGMAR1 (0.44) | SIGMAR1KDM4EALDH1A1FAAHMEN1 | |
| SCHEMBL8487208 | 0.73 | MEN1 (0.47) | SIGMAR1KDM4EALDH1A1FAAHMEN1 | |
| SCHEMBL8491628 | 0.73 | CYP2D6 (0.48) | SIGMAR1KDM4EALDH1A1FAAHMEN1 | |
| SCHEMBL7373091 | 0.72 | SIGMAR1 (0.54) | SIGMAR1KDM4EALDH1A1FAAHMEN1 | |
| SCHEMBL24199876 | 0.71 | SIGMAR1 (0.68) | SIGMAR1KDM4EALDH1A1FAAHLMNA | |
| SCHEMBL8487205 | 0.70 | HSD17B10 (0.57) | SIGMAR1KDM4EALDH1A1FAAHMEN1 | |
| SCHEMBL7372510 | 0.69 | SIGMAR1 (0.51) | SIGMAR1KDM4EALDH1A1FAAHMEN1 | |
| SCHEMBL28217942 | 0.68 | SIGMAR1 (1.00) | SIGMAR1KDM4EALDH1A1FAAHMEN1 | |
| SCHEMBL7373086 | 0.68 | KDM4E (0.58) | SIGMAR1KDM4EALDH1A1FAAHMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929074-A | VSODILATOR, ANTIALLERGIC AND ANTIPLATELET AGENTS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1999-07-27 | — | — | US | disclosed |
| EP-0706517-B1 | PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY | NISSAN CHEMICAL IND LTD (JP) | 1998-10-21 | — | — | EP | disclosed |
| US-5728702-A | BRONCHODILATOR AGENTS, ANTIALLERGENS OR ANTIPLATELET DRUGGS | NISSAN CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-17 | — | — | US | disclosed |
| EP-0706517-A1 | PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY | NISSAN CHEMICAL INDUSTRIES, LIMITED (JP) | 1996-04-17 | — | — | EP | disclosed |
| WO-1995001343-A1 | PYRIDAZINONE DERIVATIVES WITH PHARMACEUTICAL ACTIVITY | NISSAN CHEMICAL INDUSTRIES LTD. (JP) | 1995-01-12 | — | — | WO | disclosed |