Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2E1 | P05181 | 7/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 7/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 7/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.33 |
| ▸ | CYP2C8 | P10632 | 4/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10983582 | 0.83 | CYP2D6 (0.41) | CYP2E1CYP2D6CYP2A6CYP2B6CYP2C19 | |
| SCHEMBL6695496 | 0.83 | CYP2D6 (0.41) | CYP2E1CYP2D6CYP2A6CYP2B6CYP2C19 | |
| SCHEMBL6602472 | 0.81 | CYP2D6 (0.39) | CYP2E1CYP2D6CYP2A6CYP2B6CYP2C19 | |
| SCHEMBL19558728 | 0.78 | CYP2E1 (0.37) | CYP2E1CYP2D6CYP2A6CYP2B6CYP2C19 | |
| SCHEMBL22889494 | 0.77 | MEN1 (0.31) | — | |
| Oxalic Acid SCHEMBL5111812 | 0.76 | CYP2E1 (0.37) | CYP2E1CYP2D6CYP2A6CYP2B6CYP2C19 | |
| SCHEMBL31192239 | 0.72 | ALDH1A1 (0.45) | CYP2E1CYP2D6CYP2A6CYP2B6CYP2C19 | |
| SCHEMBL11022822 | 0.72 | PRMT6 (0.35) | CYP2E1CYP2D6CYP2A6CYP2B6CYP2C19 | |
| SCHEMBL30704427 | 0.71 | — | — | |
| SCHEMBL183214 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |