Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 7/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 7/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 7/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.39 |
| ▸ | CYP2E1 | P05181 | 6/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 4/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL5111812 | 0.89 | CYP2E1 (0.37) | CYP2D6CYP2A6CYP2B6CYP2C19CYP2E1 | |
| SCHEMBL6695496 | 0.84 | CYP2D6 (0.41) | CYP2D6CYP2A6CYP2B6CYP2C19CYP2E1 | |
| SCHEMBL10983582 | 0.84 | CYP2D6 (0.41) | CYP2D6CYP2A6CYP2B6CYP2C19CYP2E1 | |
| SCHEMBL7371111 | 0.81 | CYP2E1 (0.38) | CYP2D6CYP2A6CYP2B6CYP2C19CYP2E1 | |
| SCHEMBL11088334 | 0.81 | ALDH1A1 (0.39) | CYP2A6CYP2C19CYP2C9CYP1A2 | |
| Hydrochloric Acid SCHEMBL10912134 | 0.79 | ALDH1A1 (0.38) | CYP2A6CYP2C19CYP2C9CYP1A2 | |
| SCHEMBL19558728 | 0.79 | CYP2E1 (0.37) | CYP2D6CYP2A6CYP2B6CYP2C19CYP2E1 | |
| SCHEMBL11198860 | 0.76 | ACHE (0.32) | — | |
| SCHEMBL11172601 | 0.76 | PRMT6 (0.55) | CYP2D6CYP2C19CYP2C9CYP3A4CYP1A2 | |
| SCHEMBL2478908 | 0.76 | CYP3A4 (0.41) | CYP2D6CYP2A6CYP2B6CYP2C19CYP2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436269-A1 | OXADIAZOLYL-BIPHENYLCARBOXAMIDES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003033482-A1 | OXADIAZOLYL-BIPHENYLCARBOXAMIDES AND THEIR USE AS P38 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2003-04-24 | — | — | WO | disclosed |