Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.50 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.50 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.49 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sb-202474 SCHEMBL6469103 | 0.83 | TGFBR1 (1.00) | TGFBR1MAPTALOX5MAPK13MAPK12 | |
| SCHEMBL7374799 | 0.83 | SMPD3 (0.56) | TGFBR1KDM4EALDH1A1HPGDMAPT | |
| Sb-202474 SCHEMBL31118901 | 0.82 | TGFBR1 (0.97) | TGFBR1MAPTALOX5MAPK13MAPK12 | |
| SCHEMBL7374031 | 0.81 | MPO (0.47) | TGFBR1KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL6449315 | 0.80 | MAPK11 (0.72) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL7365842 | 0.79 | TGFBR1 (0.70) | TGFBR1NPC1ALOX5MAPK13MAPK12 | |
| SCHEMBL6465030 | 0.79 | MAPK13 (0.71) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL6469680 | 0.78 | MAPK13 (0.69) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL15075623 | 0.76 | MAPK13 (0.71) | KDM4EALDH1A1HPGDMAPTLMNA | |
| SCHEMBL67076 | 0.74 | KDM4E (0.52) | KDM4EALDH1A1HPGDMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4822805-A | ANTIINFLAMMATORY AGENTS, CARDIOTONIC AGENTS, ANTIPLATELET AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1989-04-18 | — | — | US | disclosed |
| EP-0257897-A1 | Imidazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-03-02 | — | — | EP | disclosed |