Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 8/20 | 0.58 |
| ▸ | ITGA2B | P08514 | 8/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | HTR3A | P46098 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.37 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7371120 | 0.89 | ITGB3 (0.57) | ITGB3ITGA2BTDP1SLC6A2SLC6A4 | |
| SCHEMBL7411595 | 0.81 | GPR119 (0.46) | ITGB3ITGA2BCHEK2 | |
| SCHEMBL7376490 | 0.81 | ITGB3 (0.58) | ITGB3ITGA2BCHEK2 | |
| Hydrochloric Acid SCHEMBL9409442 | 0.75 | ITGB3 (0.53) | ITGB3ITGA2BTDP1SLC6A2SLC6A4 | |
| SCHEMBL7848169 | 0.74 | ITGB3 (0.45) | ITGB3ITGA2BTDP1SLC6A4 | |
| SCHEMBL7373945 | 0.74 | ITGB3 (1.00) | ITGB3ITGA2BTDP1CHEK2 | |
| SCHEMBL7371499 | 0.74 | ITGB3 (1.00) | ITGB3ITGA2BTDP1CHEK2 | |
| SCHEMBL7372389 | 0.72 | GPR119 (0.44) | CHEK2 | |
| SCHEMBL7371808 | 0.71 | CHEK2 (0.46) | ITGB3ITGA2BCHEK2 | |
| SCHEMBL4688420 | 0.70 | TDP1 (0.60) | ITGB3ITGA2BTDP1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6114328-A | ANTICOAGULANTS; BLOOD DISORDERS | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-09-05 | — | — | US | disclosed |
| EP-0970950-A2 | Novel isoxazoline and isoxazole fibrinogen receptor antagonists | DuPont Pharmaceuticals Company (US) | 2000-01-12 | — | — | EP | disclosed |
| WO-1995014683-A1 | NOVEL ISOXAZOLINE AND ISOXAZOLE FIBRINOGEN RECEPTOR ANTAGONISTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-06-01 | — | — | WO | disclosed |