Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7372389 | 0.91 | GPR119 (0.44) | GPR119CHEK2FAAHCSF1RHDAC1 | |
| SCHEMBL7371808 | 0.91 | CHEK2 (0.46) | GPR119CHEK2ITGB3ITGA2BCSF1R | |
| SCHEMBL7835827 | 0.87 | CHEK2 (0.45) | GPR119CHEK2CSF1RHDAC1 | |
| SCHEMBL7372351 | 0.85 | GPR119 (0.51) | GPR119CHEK2ITGB3ITGA2BFAAH | |
| SCHEMBL7371502 | 0.81 | ITGB3 (0.58) | CHEK2ITGB3ITGA2B | |
| SCHEMBL7411472 | 0.81 | GPR119 (0.50) | GPR119CHEK2FAAHCSF1R | |
| SCHEMBL7411590 | 0.79 | ITGB3 (0.69) | GPR119CHEK2ITGB3ITGA2BFAAH | |
| SCHEMBL3249170 | 0.75 | KDM4E (0.61) | GPR119CHEK2CSF1RKDM4EPKM | |
| SCHEMBL65285 | 0.74 | GPR119 (0.59) | GPR119CHEK2HDAC1KDM4EPKM | |
| SCHEMBL12834985 | 0.74 | GPR119 (0.58) | GPR119CHEK2CSF1RHDAC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0730590-B1 | ISOXAZOLINE AND ISOXAZOLE FIBRINOGEN RECEPTOR ANTAGONISTS | DU PONT PHARM CO (US) | 2001-01-17 | — | — | EP | disclosed |
| US-6114328-A | ANTICOAGULANTS; BLOOD DISORDERS | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-09-05 | — | — | US | disclosed |
| EP-0970950-A2 | Novel isoxazoline and isoxazole fibrinogen receptor antagonists | DuPont Pharmaceuticals Company (US) | 2000-01-12 | — | — | EP | disclosed |
| WO-1995014683-A1 | NOVEL ISOXAZOLINE AND ISOXAZOLE FIBRINOGEN RECEPTOR ANTAGONISTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-06-01 | — | — | WO | disclosed |