Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 9/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.39 |
| ▸ | TPSAB1 | Q15661 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7371601 | 0.80 | ITGB3 (0.51) | GLSPRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL7371595 | 0.80 | ITGB3 (0.51) | GLSPRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL7371589 | 0.77 | GLS (0.47) | GLSFFAR1SMN1; SMN2PRSS1PRSS2 | |
| SCHEMBL8176914 | 0.76 | SYK (0.44) | GLSPRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL8176909 | 0.76 | SYK (0.44) | GLSPRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL7376134 | 0.73 | CA12 (0.56) | SMN1; SMN2HTT | |
| SCHEMBL15724934 | 0.71 | GLS (0.65) | GLSFFAR1 | |
| SCHEMBL7415486 | 0.71 | CA12 (0.56) | SMN1; SMN2HTT | |
| SCHEMBL27346972 | 0.71 | CA12 (0.59) | SMN1; SMN2HTT | |
| SCHEMBL7105678 | 0.70 | TDP1 (0.57) | SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1049693-A1 | 1,3,4-THIADIAZOLES AND 1,3,4-OXADIAZOLES AS $g(a) v?$g(b) 3? ANTAGONISTS | Du Pont Pharmaceuticals Company (US) | 2000-11-08 | — | — | EP | disclosed |
| WO-1999026945-A1 | 1,3,4-THIADIAZOLES AND 1,3,4-OXADIAZOLES AS αvβ3 ANTAGONISTS | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-06-03 | — | — | WO | disclosed |