Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 14/20 | 0.51 |
| ▸ | ITGA2B | P08514 | 12/20 | 0.51 |
| ▸ | ITGAV | P06756 | 9/20 | 0.51 |
| ▸ | GLS | O94925 | 3/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.44 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.44 |
| ▸ | ECE1 | P42892 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7371595 | 1.00 | ITGB3 (0.51) | ITGB3ITGA2BITGAVGLSPRSS1 | |
| SCHEMBL8176909 | 0.90 | SYK (0.44) | ITGB3ITGA2BITGAVGLSPRSS1 | |
| SCHEMBL8176914 | 0.90 | SYK (0.44) | ITGB3ITGA2BITGAVGLSPRSS1 | |
| SCHEMBL8177114 | 0.85 | ITGB3 (0.61) | ITGB3ITGA2BITGAVGLS | |
| SCHEMBL8177121 | 0.85 | ITGB3 (0.61) | ITGB3ITGA2BITGAVGLS | |
| SCHEMBL7371589 | 0.84 | GLS (0.47) | ITGB3ITGA2BGLSPRSS1PRSS2 | |
| SCHEMBL8177327 | 0.82 | ITGB3 (0.60) | ITGB3ITGA2BITGAV | |
| SCHEMBL8177321 | 0.81 | ITGB3 (0.42) | ITGB3ITGA2BITGAVGLS | |
| SCHEMBL7371577 | 0.80 | GLS (0.46) | GLSPRSS1PRSS2PRSS3TPSAB1 | |
| SCHEMBL8176780 | 0.77 | SYK (0.42) | ITGB3ITGA2BITGAVGLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1049693-A1 | 1,3,4-THIADIAZOLES AND 1,3,4-OXADIAZOLES AS $g(a) v?$g(b) 3? ANTAGONISTS | Du Pont Pharmaceuticals Company (US) | 2000-11-08 | — | — | EP | disclosed |
| WO-1999026945-A1 | 1,3,4-THIADIAZOLES AND 1,3,4-OXADIAZOLES AS αvβ3 ANTAGONISTS | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-06-03 | — | — | WO | disclosed |